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Research Informatics Training

 

Alistair is a PhD researcher at The Open University, undertaking their doctoral studies in collaboration with the Cambridge Centre for Proteomics under the supervision of Professor Kathryn Lilley. Their research focuses on mass spectrometry-based spatial proteomics, with the aim of gaining deeper insight into mammalian host systems used for the expression of protein therapeutics.

In parallel with their academic research, Alistair is a Senior Scientist within Biopharmaceuticals R&D at AstraZeneca, where they focus on protein characterisation using mass spectrometry, analytical method development, and the use of proteomics to better understand biomanufacturing processes. With over a decade of experience in the biopharmaceutical industry, they have deep expertise in chromatography, electrophoresis, and mass spectrometry, as well as protein purification in development-stage processes.

Alistair holds a BSc in Forensic Science from Anglia Ruskin University and brings a unique combination of academic and industrial expertise to their research and occasional contributions to university teaching and engagement activities.

Biography

Anglia Ruskin University

Forensic Science 2010 - 2013

Grade: Upper Second Class Honours


The Open University

Doctor of Philosophy - PhD, Biochemistry and Molecular Biology 2018-2025

Researching novel biological mass spectrometry methods

Publications

Key publications: 

 

Multi-Attribute Monitoring Method for Process Development of Engineered Antibody for Site-Specific Conjugation

  • June 2023
  • Journal of the American Society for Mass Spectrometry 34(7)
  • 34(7)

DOI:10.1021/jasms.3c00037


Spectral Interferences Impede the High-Resolution Mass Analysis of Recombinant Adeno-Associated Viruses

  • August 2022

DOI:10.1101/2022.08.27.505551


Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation

  • August 2021
  • Bioconjugate Chemistry XXXX(XXX)
  • XXXX(XXX)

DOI:10.1021/acs.bioconjchem.1c00286

 

Teaching and Supervisions

Teaching: 

 

2024/2025:

  • Expression proteomics analysis in R - Trainer
Alistair Hines

Contact Details

Email address: 
Department of Biochemistry
Main Building (Hopkins) Building O
Downing Site
Tennis Court Road
Cambridge
CB2 1QW