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Bioinformatics Training

 

Bioinformatician at Altos Labs, CRI

Publications

Key publications: 

Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis

SJ Clark, R Argelaguet, T Lohoff, F Krueger, D Drage, B Göttgens, ...

Genome Biology 23 (1), 1-20

  2022
Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation

M Arez, M Eckersley-Maslin, T Klobučar, J von Gilsa Lopes, F Krueger, ...

Nature Communications 13 (1), 1-20

  2022
Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function

M Ravichandran, D Rafalski, CI Davies, O Ortega-Recalde, X Nan, ...

Science Advances 8 (36), eabm2427

  2022
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses

J Rodríguez-Ubreva, A Arutyunyan, MJ Bonder, D Pino-Molina, SJ Clark, ...

Nature communications 13 (1), 1-18

  2022
8C-like cells capture the human zygotic genome activation program in vitro

J Taubenschmid-Stowers, M Rostovskaya, F Santos, S Ljung, ...

Cell stem cell 29 (3), 449-459. e6

  2022
Stimulation of adaptive gene amplification by origin firing under replication fork constraint

AJ Whale, M King, RM Hull, F Krueger, J Houseley

Nucleic acids research 50 (2), 915-936

  2022
Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes

M Suriyalaksh, C Raimondi, A Mains, A Segonds-Pichon, S Mukhtar, ...

Iscience 25 (1), 103663

  2022
NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naive pluripotent stem cells

K Maskalenka, G Alagoz, F Krueger, J Wright, M Rostovskaya, A Nakhuda, ...

bioRxiv

  2022
Decoding gene regulation in the mouse embryo using single-cell multi-omics

R Argelaguet, T Lohoff, JG Li, A Nakhuda, D Drage, F Krueger, L Velten, ...

bioRxiv

  2022
Genome-wide analysis of DNA replication and DNA double-strand breaks using TrAEL-seq

N Kara, F Krueger, P Rugg-Gunn, J Houseley

PLoS biology 19 (3), e3000886

  2021
Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle

JA Halsall, S Andrews, F Krueger, CE Rutledge, G Ficz, W Reik, ...

Scientific reports 11 (1), 1-19

  2021
The distinct effects of MEK and GSK3 inhibition upon the methylome and transcriptome of mouse embryonic stem cells

J Spindel, C Krueger, F Krueger, EK Papachristou, K Kishore, ...

bioRxiv

  2021
Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

J Rodríguez-Ubreva, A Arutyunyan, MJ Bonder, L Del Pino-Molina, ...

bioRxiv

  2021
Modelling human zygotic genome activation in 8C-like cells in vitro

J Taubenschmid-Stowers, M Rostovskaya, F Santos, S Ljung, ...

bioRxiv

  2021
Inference of emergent spatio-temporal processes in single-cell genomics

F Olmeda, T Lohoff, S Clark, L Benson, F Krueger, W Reik, S Rulands

APS March Meeting Abstracts 2021, S13. 009

  2021
Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates

F Olmeda, T Lohoff, SJ Clark, L Benson, F Krüger, W Reik, S Rulands

bioRxiv, 2020.12. 30.424823

  2021
DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes

E Ivanova, S Canovas, S Garcia-Martínez, R Romar, JS Lopes, D Rizos, ...

Clinical epigenetics 12 (1), 1-18

  2020
Correction to: DNA methylation changes during preimplantation development reveal interspecies differences and reprogramming events at imprinted genes

E Ivanova, S Canovas, S Garcia-Martínez, R Romar, JS Lopes, D Rizos, ...

Clinical Epigenetics 12 (1), 1-1

  2020
IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions

T Klobučar, E Kreibich, F Krueger, M Arez, D Pólvora-Brandão, ...

Nucleic acids research 48 (16), e92-e92

  2020
Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions

O Thompson, F von Meyenn, Z Hewitt, J Alexander, A Wood, ...

Nature communications 11 (1), 1-14

  2020

Teaching and Supervisions

Teaching: 

 

2020/2021:

  • Analysis of DNA Methylation using Sequencing - Training Lead, Trainer

2019/2020:

  • Analysis of DNA Methylation using Sequencing - Training Lead, Trainer

2018/2019:

  • Analysis of DNA Methylation using Sequencing - Training Lead, Trainer

2017/2018:

  • Analysis of DNA Methylation using Sequencing - Training Lead, Trainer

2016/2017:

  • Analysis of DNA Methylation using Sequencing - Training Lead, Trainer

2015/2016:

  • Analysis of DNA Methylation using Sequencing - Training Lead, Trainer
Felix Krueger

Contact Details

Email address: 
Altos Labs
Granta Park
Great Abington
CB21 6GP