Shanlin Rao, DPhil

Postdoctoral Research Associate (Department of Pharmacology)

Biography

Education:

University of Oxford: Oxford, Oxfordshire, GB

2016-10 to 2021-01 | DPhil (Department of Biochemistry)

University of Oxford: Oxford, Oxfordshire, GB

2012-10 to 2016-07 | MBiochem

Publications

Key publications:

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca2+-sensor ALG-2

Proceedings of the National Academy of Sciences of the United States of America

2024-02-27 | Journal article

DOI: 10.1073/pnas.2318046121

Contributors: Sankalp Shukla; Wei Chen; Shanlin Rao; Serim Yang; Chenxi Ou; Kevin P. Larsen; Gerhard Hummer; Phyllis Hanson; James Hurley

Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore

Science Advances

2024-02-09 | Journal article

DOI: 10.1126/sciadv.adj8027

Contributors: Shanlin Rao; Marvin Skulsuppaisarn; Lisa M. Strong; Xuefeng Ren; Michael Lazarou; James H. Hurley; Gerhard Hummer

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca2+-sensor ALG-2

2023-10-19 | Preprint

DOI: 10.1101/2023.10.17.562764

Contributors: Sankalp Shukla; Wei Chen; Shanlin Rao; Serim Yang; Chenxi Ou; Kevin P. Larsen; Gerhard Hummer; Phyllis I. Hanson; James H. Hurley

Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15

2023-09-28 | Preprint

DOI: 10.1101/2023.09.28.559894

Contributors: Annan S. I. Cook; Minghao Chen; Xuefeng Ren; Shanlin Rao; Samantha N. Garcia; Ainara Claveras Cabezudo; Anthony T. Iavarone; Gerhard Hummer; James H. Hurley

Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore

2023-07-17 | Preprint

DOI: 10.1101/2023.07.17.549391

Contributors: Shanlin Rao; Lisa M. Strong; Xuefeng Ren; Marvin Skulsuppaisarn; Michael Lazarou; James H. Hurley; Gerhard Hummer

Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery

Science Advances

2022-12 | Journal article

DOI: 10.1126/sciadv.add1436

PMID: 36516251

PMC: PMC9750143

Contributors: Liv E Jensen; Shanlin Rao; Martina Schuschnig; A. King Cada; Sascha Martens; Gerhard Hummer; James Hurley

Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea

Nature Genetics

2022-10 | Journal article

DOI: 10.1038/s41588-022-01185-x

PMID: 36195757

PMC: PMC9534757

Contributors: Janina Sörmann; Marcus Schewe; Proks P; Thibault R. H. Jouen-Tachoire; Shanlin Rao; Elena Riel; Agre KE; Amber Begtrup; Dean J; Descartes M et al.

Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs

Nature Communications

2022-08 | Journal article

DOI: 10.1038/s41467-022-32594-5

PMID: 35982060

PMC: PMC9388682

Contributors: Arvind Kumar; Kayla Kindig; Shanlin Rao; Afroditi Maria Zaki; Basak S; Mark Sansom; Philip Biggin; sudha chakrapani

Water nanoconfined in a hydrophobic pore: Molecular dynamics simulations of transmembrane protein 175 and the influence of water models

ACS Nano

2021-12 | Journal article

DOI: 10.1021/acsnano.1c06443

PMID: 34784172

PMC: PMC7612143

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

Journal of General Physiology

2021-08 | Journal article

DOI: 10.1085/jgp.202012812

PMID: 34032848

PMC: PMC8155809

Contributors: Shanlin Rao

Defective X-gating caused byde novogain-of-function mutations inKCNK3underlies a developmental disorder with sleep apnea

2021-08-09 | Preprint

DOI: 10.1101/2021.08.05.21261490

Contributors: Janina Sörmann; Marcus Schewe; Peter Proks; Thibault Jouen-Tachoire; Shanlin Rao; Elena B. Riel; Katherine E. Agre; Amber Begtrup; John Dean; Maria Descartes et al.

Molecular simulations of hydrophobic gating of pentameric ligand gated ion channels: Insights into water and ions

Journal of Physical Chemistry B

2021-02 | Journal article

DOI: 10.1021/acs.jpcb.0c09285

PMID: 33439645

PMC: PMC7869105

The MscS-like channel YnaI has a gating mechanism based on flexible pore helices

Proceedings of the National Academy of Sciences of the United States of America

2020-11 | Journal article

DOI: 10.1073/pnas.2005641117

PMID: 33148804

PMC: PMC7682570

Multiple Mechanisms Underlie State-Independent Inhibitory Effects of Norfluoxetine on TREK-2 K2P Channels

2020-10-29 | Preprint

DOI: 10.1101/2020.10.29.360966

Contributors: Peter Proks; Marcus Schewe; Linus J. Conrad; Shanlin Rao; Kristin Rathje; Karin E. J. Rödström; Elisabeth P. Carpenter; Thomas Baukrowitz; Stephen J Tucker

Water in nanopores and biological channels: A molecular simulation perspective

Chemical Reviews

2020-09 | Journal article

DOI: 10.1021/acs.chemrev.9b00830

PMID: 32841020

PMC: PMC7517714

Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs

Nature Communications

2020-07 | Journal article

DOI: 10.1038/s41467-020-17364-5

PMID: 32719334

PMC: PMC7385131