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Bioinformatics Training

 

Scientist in Molecular Evolution at European Bioinformatics Institute

Publications

Key publications: 

 

SWAMPy: Simulating SARS-CoV-2 Wastewater Amplicon Metagenomes with Python

Boulton W, Fidan FR, De Maio N, Goldman N.

2022

doi:10.1101/2022.12.10.519890.


VGsim: Scalable viral genealogy simulator for global pandemic.

Shchur V, Spirin V, Sirotkin D, Burovski E, De Maio N, Corbett-Detig R.

PLoS Comput Biol, 2022

doi:10.1371/journal.pcbi.1010409.


Impact and mitigation of sampling bias to determine viral spread: evaluating discrete phylogeography through CTMC modeling and structured coalescent model approximations

Layan M, Müller NF, Dellicour S, De Maio N, Bourhy H, Cauchemez S, Baele G.

2022

doi:10.1101/2022.07.07.498932.


phastSim: Efficient simulation of sequence evolution for pandemic-scale datasets.

De Maio N, Boulton W, Weilguny L, Walker CR, Turakhia Y, Corbett-Detig R, Goldman N.

PLoS Comput Biol, 2022

doi:10.1371/journal.pcbi.1010056.


Accounting for spatial sampling patterns in Bayesian phylogeography.

Guindon S, De Maio N.

Proc Natl Acad Sci U S A, 2021

doi:10.1073/pnas.2105273118.


Online Phylogenetics using Parsimony Produces Slightly Better Trees and is Dramatically More Efficient for Large SARS-CoV-2 Phylogenies than <i>de novo</i> and Maximum-Likelihood Approaches

Thornlow B, Kramer A, Ye C, De Maio N, McBroome J, Hinrichs AS, Lanfear R, Turakhia Y, Corbett-Detig R.

2021

doi:10.1101/2021.12.02.471004.


Genomic reconstruction of the SARS-CoV-2 epidemic in England.

Vöhringer HS, Sanderson T, Sinnott M, De Maio N, Nguyen T, Goater R, Schwach F, Harrison I, Hellewell J, Ariani CV, Gonçalves S, Jackson DK, Johnston I, Jung AW, Saint C, Sillitoe J, Suciu M, Goldman N, Panovska-Griffiths J, Wellcome Sanger Institute COVID-19 Surveillance Team, COVID-19 Genomics UK (COG-UK) Consortium*, Birney E, Volz E, Funk S, Kwiatkowski D, Chand M, Martincorena I, Barrett JC, Gerstung M.

Nature, 2021

doi:10.1038/s41586-021-04069-y.


Using host genetics to infer the global spread and evolutionary history of HCV subtype 3a.

Lin SK, De Maio N, Pedergnana V, Wu CH, Thézé J, Wilson DJ, Barnes E, Ansari MA.

Virus Evol, 2021

doi:10.1093/ve/veab065.


A Daily-Updated Database and Tools for Comprehensive SARS-CoV-2 Mutation-Annotated Trees.

McBroome J, Thornlow B, Hinrichs AS, Kramer A, De Maio N, Goldman N, Haussler D, Corbett-Detig R, Turakhia Y.

Mol Biol Evol, 2021

doi:10.1093/molbev/msab264.


Pandemic-Scale Phylogenomics Reveals Elevated Recombination Rates in the SARS-CoV-2 Spike Region

Turkahia Y, Thornlow B, Hinrichs A, McBroome J, Ayala N, Ye C, De Maio N, Haussler D, Lanfear R, Corbett-Detig R.

2021

doi:10.1101/2021.08.04.455157.


Genetic Variability of the SARS-CoV-2 Pocketome.

Yazdani S, De Maio N, Ding Y, Shahani V, Goldman N, Schapira M.

J Proteome Res, 2021

doi:10.1021/acs.jproteome.1c00206.


A phylogenetic approach for weighting genetic sequences.

De Maio N, Alekseyenko AV, Coleman-Smith WJ, Pardi F, Suchard MA, Tamuri AU, Truszkowski J, Goldman N.

BMC Bioinformatics, 2021

doi:10.1186/s12859-021-04183-8.


Genomic reconstruction of the SARS-CoV-2 epidemic in England

Vöhringer HS, Sanderson T, Sinnott M, Maio ND, Nguyen T, Goater R, Schwach F, Harrison I, Hellewell J, Ariani C, Gonçalves S, Jackson D, Johnston I, Jung AW, Saint C, Sillitoe J, Suciu M, Goldman N, Panovska-Griffiths J, Birney E, Volz E, Funk S, Kwiatkowski D, Chand M, Martincorena I, Barrett JC, Gerstung M, The Wellcome Sanger Institute Covid-19 Surveillance Team, The COVID-19 Genomics UK (COG-UK) Consortium.

2021

doi:10.1101/2021.05.22.21257633.


Ultrafast Sample placement on Existing tRees (UShER) enables real-time phylogenetics for the SARS-CoV-2 pandemic.

Turakhia Y, Thornlow B, Hinrichs AS, De Maio N, Gozashti L, Lanfear R, Haussler D, Corbett-Detig R.

Nat Genet, 2021

doi:10.1038/s41588-021-00862-7.


Mutation Rates and Selection on Synonymous Mutations in SARS-CoV-2.

De Maio N, Walker CR, Turakhia Y, Lanfear R, Corbett-Detig R, Goldman N.

Genome Biol Evol, 2021

doi:10.1093/gbe/evab087.


The SARS-CoV-2 replication-transcription complex is a priority target for broad-spectrum pan-coronavirus drugs

Yazdani S, De Maio N, Ding Y, Shahani V, Goldman N, Schapira M.

2021

doi:10.1101/2021.03.23.436637.


phastSim: efficient simulation of sequence evolution for pandemic-scale datasets

De Maio N, Boulton W, Weilguny L, Walker CR, Turakhia Y, Corbett-Detig R, Goldman N.

2021

doi:10.1101/2021.03.15.435416.


Short-range template switching in great ape genomes explored using pair hidden Markov models.

Walker CR, Scally A, De Maio N, Goldman N.

PLoS Genet, 2021

doi:10.1371/journal.pgen.1009221.


Want to track pandemic variants faster? Fix the bioinformatics bottleneck.

Hodcroft EB, De Maio N, Lanfear R, MacCannell DR, Minh BQ, Schmidt HA, Stamatakis A, Goldman N, Dessimoz C.

Nature, 2021

doi:10.1038/d41586-021-00525-x.


Global spread and evolutionary history of HCV subtype 3a

lin S, De Maio N, Pedergnana V, Wu C, Thézé J, Barnes E, Ansari MA.

2021

doi:10.1101/2021.02.03.429581.


Mutation rates and selection on synonymous mutations in SARS-CoV-2

De Maio N, Walker CR, Turakhia Y, Lanfear R, Corbett-Detig R, Goldman N.

2021

doi:10.1101/2021.01.14.426705.


Sampling bias and model choice in continuous phylogeography: Getting lost on a random walk.

Kalkauskas A, Perron U, Sun Y, Goldman N, Baele G, Guindon S, De Maio N.

PLoS Comput Biol, 2021

doi:10.1371/journal.pcbi.1008561.


A Phylodynamic Workflow to Rapidly Gain Insights into the Dispersal History and Dynamics of SARS-CoV-2 Lineages.

Dellicour S, Durkin K, Hong SL, Vanmechelen B, Martí-Carreras J, Gill MS, Meex C, Bontems S, André E, Gilbert M, Walker C, Maio N, Faria NR, Hadfield J, Hayette MP, Bours V, Wawina-Bokalanga T, Artesi M, Baele G, Maes P.

Mol Biol Evol, 2021

doi:10.1093/molbev/msaa284.


The Cumulative Indel Model: Fast and Accurate Statistical Evolutionary Alignment.

De Maio N.

Syst Biol, 2021

doi:10.1093/sysbio/syaa050.


Masking strategies for SARS-CoV-2 alignments

De Maio N, Walker C, Borges R, Weilguny L, Slodkowicz G, Goldman N.

2020

doi:.


Issues with SARS-CoV-2 sequencing data

De Maio N, Walker C, Borges R, Weilguny L, Slodkowicz G, Goldman N.

2020

doi:.


Phylogenetic Novelty Scores: a New Approach for Weighting Genetic Sequences

De Maio N, Alekseyenko AV, Coleman-Smith WJ, Pardi F, Suchard MA, Tamuri AU, Truszkowski J, Goldman N.

2020

doi:10.1101/2020.12.03.410100.


Stability of SARS-CoV-2 phylogenies.

Turakhia Y, De Maio N, Thornlow B, Gozashti L, Lanfear R, Walker CR, Hinrichs AS, Fernandes JD, Borges R, Slodkowicz G, Weilguny L, Haussler D, Goldman N, Corbett-Detig R.

PLoS Genet, 2020

doi:10.1371/journal.pgen.1009175.


Short-range template switching in great ape genomes explored using a pair hidden Markov model

Walker CR, Scally A, De Maio N, Goldman N.

2020

doi:10.1101/2020.11.09.374694.


Repeated global migrations on different plant hosts by the tropical pathogen<i>Phytophthora palmivora</i>

Wang J, Coffey MD, De Maio N, Goss EM.

2020

doi:10.1101/2020.05.13.093211.


A phylodynamic workflow to rapidly gain insights into the dispersal history and dynamics of SARS-CoV-2 lineages

Dellicour S, Durkin K, Hong SL, Vanmechelen B, Martí-Carreras J, Gill MS, Meex C, Bontems S, André E, Gilbert M, Walker C, De Maio N, Faria NR, Hadfield J, Hayette M, Bours V, Wawina-Bokalanga T, Artesi M, Baele G, Maes P.

2020

doi:10.1101/2020.05.05.078758.


Sampling bias and model choice in continuous phylogeography: getting lost on a random walk

Kalkauskas A, Perron U, Sun Y, Goldman N, Baele G, Guindon S, De Maio N.

2020

doi:10.1101/2020.02.18.954057.


Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design

Weilguny L, De Maio N, Munro R, Manser C, Birney E, Loose M, Goldman N.

2020

doi:10.1101/2020.02.07.938670.


Genomic diversity affects the accuracy of bacterial single-nucleotide polymorphism-calling pipelines.

Bush SJ, Foster D, Eyre DW, Clark EL, De Maio N, Shaw LP, Stoesser N, Peto TEA, Crook DW, Walker AS.

Gigascience, 2020

doi:10.1093/gigascience/giaa007.


The impact of sequencing depth on the inferred taxonomic composition and AMR gene content of metagenomic samples.

Gweon HS, Shaw LP, Swann J, De Maio N, AbuOun M, Niehus R, Hubbard ATM, Bowes MJ, Bailey MJ, Peto TEA, Hoosdally SJ, Walker AS, Sebra RP, Crook DW, Anjum MF, Read DS, Stoesser N, REHAB consortium.

Environ Microbiome, 2019

doi:10.1186/s40793-019-0347-1.

Teaching and Supervisions

Teaching: 

 

2024/2025:

  • Foundations of phylogenetic inference - Training Lead, Trainer

2023/2024:

  • Introduction to Phylogenetics - Training Lead, Trainer
  • Working with Bacterial Genomes - Trainer

2022/2023:

  • Introduction to Phylogenetics - Training Lead, Trainer

2019/2020:

  • Molecular Phylogenetics - Training Lead, Trainer

2018/2019:

  • Molecular Phylogenetics - Training Lead, Trainer

2017/2018:

  • Molecular Phylogenetics - Trainer
Nicola De Maio

Contact Details

Email address: 
European Bioinformatics Institute (EMBL-EBI)
Wellcome Genome Campus
Hinxton
Cambridgeshire
CB10 1SD