Postdoctoral Research Fellow, Francis Crick Institute
Biography
PROFESSIONAL EXPERIENCE
2022 – present KINGS COLLEGE LONDON and FRANCIS CRICK INSTITUTE, UK
Postdoctoral Research Fellow - PI: Dr. Gerard I. Evan
Myc oncogene cooperation with Ras; Immunotherapy in non-small cell lung cancer
2012 – 2022 UNIVERSITY OF CAMBRIDGE, UK
Postdoctoral Research Associate - PI: Dr. Gerard I. Evan
(Nature Comms 2022, Cancer Discovery 2020, PNAS 2019, Cell 2017, Cancer Cell 2015)
2008 – 2012 UNIVERSITY OF CALIFORNIA SAN FRANCISCO, USA
Postdoctoral Fellow - PI: Dr. Gerard I. Evan
(Neoplasia 2011, Nature 2010)
1999 –2002 THE NETHERLANDS CANCER INSTITUTE
Research Technician - PI: Dr. René Bernards
(J. Biol. Chem. 2002)
EDUCATION
2002 – 2008 THE NETHERLANDS CANCER INSTITUTE
PhD 2008. PI: Dr. René Bernards
Thesis: Escaping growth arrest in cancer – Bypass of a p53 dependent cell cycle arrest
(Mol. Cancer Res. 2008, J. Biol. Chem. 2008, Cell Cycle 2006, Nat. Cell Biol. 2006)
1993 – 1999 LEIDEN UNIVERSITY, NETHERLANDS
B.Sc. 1994. Thesis: Role of the tRNA-like 3’ end of TYMV RNA in the (-) strand synthesis.
(Virology, 1997).
1988 – 1993 ROTTERDAM UNIVERSITY OF APPLIED SCIENCES, NETHERLANDS
B.Sc. 1993. Thesis: Isolation and identification of an S. Kluyverii toxin for use as a biopreservative. DSM
Chemicals, Delft, The Netherlands.
Publications
1. Abbosh C, Frankell AM, Harrison T, Kisistok J, Garnett A, …Kortlever RM, …Birkbak NJ, McGranahan N, Swanton C. High resolution phylogenetic ctDNA predicts relapse risk and metastatic dissemination patterns in early-stage lung cancer, Nature 2023, Accepted.
2 Sodir NM, Pellegrinet L, Kortlever RM, Campos T, Kwon Y-W, Kim S, Garcia D, Perfetto A, Anastasiou P, Brown Swigart L, Arends MJ, Littlewood TD, Evan GI. Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution, Nature Communications 2022 November (13) 6782.
3. Sodir NM, Kortlever RM, Barthet VJA, Campos T, Pellegrinet L, Kupczak S, Anastasiou P, Brown Swigart L, Soucek L, Arends, MJ, Littlewood TD, Evan GI. Myc instructs and maintains pancreatic adenocarcinoma phenotype, Cancer Discovery 2020 April; 10 (4):588-607.
4. Kreuzaler P, Clarke MA, Brown EJ, Wilson CH, Kortlever RM, Piterman N, Littlewood T, Evan GI, Fisher J. PNAS 2019 Oct; 116 (44); 22399-22408.
5. Kortlever RM, Sodir NM, Wilson CH, Burkhart DL, Pellegrinet L, Brown Swigart L, Littlewood TD, Evan GI. Myc cooperates with Ras by programming inflammation and immune suppression, Cell 2017 Nov; 171 (6): 1301-1315
6. von Eyss B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, McDuffus L-A, Sauer M, Rosenwald A, I. Evan GI, Kempa S, Eilers M, A MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast cancer, Cancer Cell 2015 Dec; 28 (6):743-57.
7. Soucek L, Buggy JJ, Kortlever R, Adimoolam S, Monclús HA, Allende MT, Swigart LB, Evan GI. Modeling pharmacological inhibition of mast cell degranulation as a therapy for insulinoma. Neoplasia 2011 Nov; 13 (11):1093-100.
8. Junttila MR, Karnezis AN, Garcia D, Madriles F, Kortlever RM, Rostker F, Brown Swigart L, Pham DM, Seo Y, Evan GI, Martins CP. Selective activation of p53-mediated suppression in high-grade tumors. Nature 2010 Nov 25; 468 (7323):567- 71.
9. Kortlever RM, Brummelkamp TR, van Meeteren LA, Moolenaar WH, Bernards R. Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling. Mol Cancer Res. 2008 Sep; 6 (9):1452-60.
10. Kortlever RM, Nijwening JH, Bernards R. Transforming growth factor-ß requires its target plasminogen activator inhibitor-1 for cytostatic activity. J Biol Chem. 2008 Sep; 283 (36):24308-13.
11. Kortlever RM and Bernards, R. Senescence, wound healing, and cancer: the PAI-1 connection. Cell Cycle 2006 Dec; 5 (23):2697-703.
12. Kortlever RM, Higgins PJ, Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol. 2006 Aug; 8 (8):877-84.
13. Brummelkamp TR, Kortlever RM, Lingbeek M, Trettel F, MacDonald ME, van Lohuizen M, Bernards R. TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J Biol Chem. 2002 Feb; 277 (8):6567-72.
14. Deiman BA, Kortlever RM, Pleij CW. The role of the pseudoknot at the 3' end of turnip yellow mosaic virus RNA in (-)- strand synthesis by the viral RNA-dependent RNA polymerase. Virology 1997 Aug; 71 (8):5990
Teaching and Supervisions
2022/2023:
- Analysis of Single-cell RNA-seq Data - Training Lead, Trainer
2021/2022:
- Analysis of Single-cell RNA-seq Data - Trainer
