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Research Informatics Training

 

I am a senior postdoc working at the Milner Therapeutics Institute (University of Cambridge). I focus on computational silico drug discovery pipelines from early target identification, drug repurposing and combinatorial compound approaches. A core part of my work involves analysis of multi-omics next-generation sequencing (NGS) datasets as well as constructing and interrogating biological networks.

Biography


  • UCL

    •  Doctor of Philosophy - PhDCell Biology

    • Activities and Societies: My PhD was focused on modelling and investigating the signalling pathways of an inherited skin disorder called lamellar ichthyosis.


  • UCL

    • Master's degreeMRes Biomedicine

    • 2009 - 2010


  • King's College London

    • Bachelor of Science - BSMolecular Genetics

    • 2005 - 2008

Publications

Key publications: 

 

A CD24+CD271+ melanoma cancer stem cell possesses hybrid characteristics of its single marker counterparts and promotes invasion and therapeutic resistance

O Knowles, P Doldan, I Hillier-Richardson, S Lunetto, S Lunt, G Youssef, ...

BMC biology 23 (1), 235

  2025
A systems-level machine learning approach uncovers therapeutic targets in clear cell renal cell carcinoma

SR Estevez, G Baltusyte, G Youssef, N Han

bioRxiv, 2025.05. 26.656158

  2025
Combined stem cell and predictive models reveal flavin cofactors as targets in metabolic liver dysfunction

J Weihs, F Baldo, A Cardinali, G Youssef, K Ludwik, N Haep, P Tang, ...

bioRxiv, 2024.10. 10.617610

  2024
Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease

TW Dennison, RD Edgar, F Payne, KM Nayak, ADB Ross, A Cenier, ...

Gut 73 (9), 1464-1477

  2024
Surgical Management of Submucous Cleft Palate by Radical Muscle Dissection Veloplasty: Speech Outcomes in Patients with 22q11. 2 Deletion Syndrome

AM Ghanem, TM Borg, G Youssef, D Ridout, O Gilleard, M Birch, D Sell, ...

The Cleft Palate Craniofacial Journal 61 (3), 498-507

  2024
Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning

G Youssef, L Gammon, L Ambler, S Lunetto, A Scemama, H Cottom, ...

Elife 12, e90298

  2023
Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype

H Tagoe, S Hassan, E Bliss, G Youssef, W Heywood, K Mills, JI Harper, ...

British Journal of Dermatology 189 (1), 91-102

  2023
Dialogi: utilising NLP with chemical and disease similarities to drive the identification of Drug-Induced Liver Injury literature

NM Katritsis, A Liu, G Youssef, S Rathee, M MacMahon, W Hwang, ...

Frontiers in Genetics 13, 894209

  2022
DILI C : An AI-Based Classifier to Search for Drug-Induced Liver Injury Literature

S Rathee, M MacMahon, A Liu, NM Katritsis, G Youssef, W Hwang, ...

Frontiers in genetics 13, 867946

  2022
583 RNA sequencing of immortalised balding and non balding DPCs identifies potential balding gene signatures

R Borhan, J Lee, M Philpott, G Youssef, M Rahman, A Bensussan

Journal of Investigative Dermatology

  2022
A novel three-in-one silicone model for basic microsurgery training

O Alser, G Youssef, S Myers, AM Ghanem

European Journal of Plastic Surgery 43 (5), 621-626

  2020
Craniomaxillofacial war injuries in Misrata, Libya

AW Zaggut, MM Rahman, G Youssef, S Holmes, H Ellamushi, M Shibu, ...

Journal of Dentistry Open Access

  2020
Disseminating cells in human tumours acquire an EMT stem cell state that is predictive of metastasis

G Youssef, L Gammon, L Ambler, B Wicker, S Patel, H Cottom, K Piper, ...

bioRxiv, 2020.04. 07.029009

  2020
585 Identifying cancer stem cells in patient specimens through high-content imaging-biological insights and prognostic potential

G Youssef, H Cottoms, K Piper, L Gammon, O Knowles, SA Lunt, ...

Journal of Investigative Dermatology 139 (9), S315

  2019
The presence of Y674/Y675 phosphorylated NTRK1 via TP53 repression of PTPN6 expression as a potential prognostic marker in neuroblastoma

G Youssef, C Gillett, D Rampling, T Chagtai, A Virasami, J Barton, ...

Human Pathology 86, 182-192

  2019
Identification of a novel cancer stem cell subpopulation in melanoma pathological specimens

O Knowles, P Doldan, I Hillier-Richardson, S Lunt, L Gammon, G Youssef, ...

  2018
108 Targeting the toll-like receptor pathway to treat scaling in the autosomal recessive congenital ichthyoses

S Hassan, H Tagoe, G Youssef, R O’Shaughnessy

Journal of Investigative Dermatology 136 (9), S179

  2016
Mechanisms of Hyperkeratosis in Autosomal Recessive Congenital Ichthyosis (ARCI)

G Youssef

UCL (University College London)

  2016
Ovine pulmonary adenocarcinoma: a large animal model for human lung cancer

G Youssef, WAH Wallace, MP Dagleish, C Cousens, DJ Griffiths

ILAR journal 56 (1), 99-115

  2015
Abstract LB-328: SHP-1, p53 and Y674/Y675-phosphorylated-trkA: a molecular pathway and prognostic marker for neuroblastoma

G Youssef, C Gillet, D Rampling, M Chagtay, A Virasami, N Sebire, ...

Cancer Research 74 (19_Supplement), LB-328-LB-328

  2014

Teaching and Supervisions

Teaching: 

 

2024/2025:

  • Introduction to Python - Trainer
  • Introduction to R - Trainer

2023/2024:

  • Introduction to Python - Trainer

2022/2023:

  • Introduction to Machine Learning - Trainer
  • Introduction to Python - Trainer
Gehad Youssef

Contact Details

Email address: 
Milner Therapeutics Institute
University of Cambridge
Jeffrey Cheah Biomedical Centre
Puddicombe Way
Cambridge
CB2 0AW