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Bioinformatics Training

 

Senior Bioinformatician at Tropic Biosciences

I am a versatile scientist with more than five years of experience working with large-scale genomic data starting from NGS data generation, processing of raw reads to data analysis and data visualisation. I have deep domain knowledge in plant science, cancer, epigenetics, virology. Trained as a pharmacist, I also have deep understanding of human physiology, pathology and drug discovery processes.
I am seeking to apply my expertise of data science, computational biology and profound domain knowledge, obtained as a leading academic, to real world problems in biotech industry.

Publications

Key publications: 

  • The G-box transcriptional regulatory code in Arabidopsis. The G-box transcriptional regulatory code in Arabidopsis.

    Plant Physiol. 175, pp.01086.2017 (2017) · Oct 1, 2017Plant Physiol. 175, pp.01086.2017 (2017) · Oct 1, 2017

      • Ezer, D., Shepherd, SJK., Brestovitsky, A., Dickinson, P., Cortijo, S., Charoensawan, V., Box, MS.,, Biswas S., Jaeger, KE., Wigge, PA. The G-box transcriptional regulatory code in Arabidopsis. Plant Physiol. 175, pp.01086.2017 (2017).Ezer, D., Shepherd, SJK., Brestovitsky, A., Dickinson, P., Cortijo, S., Charoensawan, V., Box, MS.,, Biswas S., Jaeger, KE., Wigge, PA. The G-box transcriptional regulatory code in Arabidopsis. Plant Physiol. 175, pp.01086.2017 (2017).


  • Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis.Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis.

    Mol. Plant 10, 1258–1273 (2017) · Oct 1, 2017Mol. Plant 10, 1258–1273 (2017) · Oct 1, 2017

      • Cortijo, S., Charoensawan, V., Brestovitsky, A., Buning, R., Ravarani, C., Rhodes, D., van Noort, J., Jaeger, KE., Wigge, PA. Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis. Mol. Plant 10, 1258–1273 (2017).Cortijo, S., Charoensawan, V., Brestovitsky, A., Buning, R., Ravarani, C., Rhodes, D., van Noort, J., Jaeger, KE., Wigge, PA. Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis. Mol. Plant 10, 1258–1273 (2017).


  • The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.

    PLoS Pathog · Feb 1, 2016PLoS Pathog · Feb 1, 2016

      • Brestovitsky, A. ¶, Nebenzahl-Sharon K. ¶, Kechker, P., Sharf, R. & Kleinberger, T. The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response. PLoS Pathog. 12, (2016) (¶-contributed equally); the article has been featured by editor.Brestovitsky, A. ¶, Nebenzahl-Sharon K. ¶, Kechker, P., Sharf, R. & Kleinberger, T. The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response. PLoS Pathog. 12, (2016) (¶-contributed equally); the article has been featured by editor.


  • Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death.Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death.

    J. Vis. Exp.(68), e4442, doi:10.3791/4442 (2012). · Jan 1, 2013J. Vis. Exp.(68), e4442, doi:10.3791/4442 (2012). · Jan 1, 2013

      • Brestovitsky, A., Sharf, R., Kleinberger, T. Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death. J. Vis. Exp.(68), e4442, doi:10.3791/4442 (2012).Brestovitsky, A., Sharf, R., Kleinberger, T. Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death. J. Vis. Exp.(68), e4442, doi:10.3791/4442 (2012).


  • The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes. The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes.

    Nucleic Acid Research · Aug 1, 2011

Teaching and Supervisions

Teaching: 

 

2018/2019:

  • Data Manipulation and Visualisation in R - Trainer
  • An Introduction to Solving Biological Problems with R - Trainer

2017/2018:

  • Data Manipulation and Visualisation in R - Trainer
  • An Introduction to Solving Biological Problems with R - Trainer
  • Data Analysis and Visualisation in R - Trainer

2016/2017:

  • Data Analysis and Visualisation in R - Trainer
  • An Introduction to Solving Biological Problems with R - Trainer
Anna Brestovitsky

Contact Details

Email address: 
Tropic Biosciences Ltd
Norwich Research Park
Innovation Centre
United Kingdom
NR4 7GJ