Senior Bioinformatics Analyst
Kamal joined Bioinformatics core at CRUK CI in 2016. His main activities involves analysis of heterogenous genomics and proteomics data. He work in close collaboration with biologists to analytically answer challenging biological questions. The development of robust software solutions with contributions to Bioconductor project forms an integral part of the work.
Biography
Kamal obtained his PhD at the University of Milan in the field of computational epigenomics. His PhD involved developing computational tools for integrative analysis of epigenomics data.
Publications
Key publications:
Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity
Apollo - University of Cambridge Repository
2022-08-15 | Journal article
DOI: 10.17863/cam.87558
Contributors: Joachim Hanna; Flavio Beke; Louise O'Brien; Chrysa Kapeni; Hung-Chang Chen; Valentina Carbonaro; Alexander Kim; Kamal Kishore; Timon Adolph; Mikkel-Ole Skjoedt et al.
Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity.
Nature communications
2022-07 | Journal article
PMID: 35835905
PMC: PMC9281293
Contributors: Hanna J; Beke F; O'Brien LM; Kapeni C; Chen HC; Carbonaro V; Kim AB; Kishore K; Adolph TE; Skjoedt MO et al.
Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.
Apollo - University of Cambridge Repository
2022-04-26 | Journal article
DOI: 10.17863/cam.83859
Contributors: Amanda Collier; Adam Bendall; Charlene Fabian; Andrew Malcolm; Katarzyna Tilgner; Claudia Semprich; Katarzyna Wojdyla; Paola Serena Nisi; Kamal Kishore; Valar Nila Roamio Franklin et al.
Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.
Science advances
2022-03 | Journal article
PMID: 35333572
PMC: PMC8956265
Contributors: Collier AJ; Bendall A; Fabian C; Malcolm AA; Tilgner K; Semprich CI; Wojdyla K; Nisi PS; Kishore K; Roamio Franklin VN et al.
DOP48 Hedgehog signalling controls Th17 differentiation to drive intestinal inflammation and is a druggable target for the treatment of IBD
Journal of Crohn's and Colitis
2022-01 | Journal article
Contributors: J Hanna; F Beke; L O’Brien; C Kapeni; H C Chen; V Carbonaro; A Kim; K Kishore; T E Adolph; M O Skjoedt et al.
GLP is critical for oogenesis exhibiting a G9A-independent role in transcriptional repression
2021-12 | Preprint
PPR: PPR434744
Contributors: Demond H; Hanna CW; Castillo-Fernandez J; Santos F; Papachristou EK; Segonds-Pichon A; Kishore K; D’Santos CS; Kelsey G
The distinct effects of MEK and GSK3 inhibition upon the methylome and transcriptome of mouse embryonic stem cells
2021-11 | Preprint
PPR: PPR422810
Contributors: Spindel J; Krueger C; Krueger F; Papachristou EK; Kishore K; D'Santos CS; Reik W
TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions.
Cell reports
2021-02 | Journal article
PMID: 33626359
Contributors: Broome R; Chernukhin I; Jamieson S; Kishore K; Papachristou EK; Mao SQ; Tejedo CG; Mahtey A; Theodorou V; Groen AJ et al.
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription.
Apollo - University of Cambridge Repository
2020-08-13 | Journal article
DOI: 10.17863/cam.56236
Contributors: Mami Oikawa; Angela Simeone; Eva Hormanseder; Marta Teperek; Vincent Gaggioli; Alan O'Doherty; Emma Falk; Matthieu Sporniak; Clive D'Santos; Valar Nila Roamio Franklin et al.
Teaching and Supervisions
Teaching:
2024/2025:
- Introduction to R - Training Lead, Trainer
2023/2024:
- Introduction to R - Training Lead, Trainer
2022/2023:
- Introduction to R - Training Lead, Trainer
- Experimental Design - Training Lead, Trainer
2021/2022:
- Introduction to R - Training Lead, Trainer
- Introduction to Python - Trainer
- Experimental Design - Training Lead, Trainer
2020/2021:
- Introduction to R - Training Lead, Trainer
2019/2020:
- Experimental Design - Training Lead, Trainer
