Sergio Martínez Cuesta, PhD

Experience

• AstraZeneca

  • Associate Director, Bioinformatics

    Full-time Nov 2022 - Present Cambridge, England, United Kingdom · On-site

    • • Group leader in hit discovery bioinformatics

        Developing research, infrastructure, strategy and training in hit and target identification for the discovery of new therapeutic modalities across multiple therapy areas inc. oncologyGroup leader in hit discovery bioinformatics Developing research, infrastructure, strategy and training in hit and target identification for the discovery of new therapeutic modalities across multiple therapy areas inc. oncology

  • Senior Data Scientist in Bioinformaticss

    Sep 2020 - Oct 2022 · 

• University of Cambridge

  • Visiting Lecturer in Bioinformatics

    • • - Delivering yearly lectures as part of the Undergraduate NST Part II BBS Bioinformatics minor
        - Developing and delivering courses in bioinformatics, machine learning and programming for life science researchers, students and staff organised by the University of Cambridge Bioinformatics Training Unit (https://bioinfotraining.bio.cam.ac.uk/)- Delivering yearly lectures as part of the Undergraduate NST Part II BBS Bioinformatics minor - Developing and delivering courses in bioinformatics, machine learning and programming for life science researchers, students and staff organised by the University of Cambridge Bioinformatics Training Unit 

  • Research Associate in Bioinformatics and Computational Biology

    2015 - 2020 Prof. Sir Shankar Balasubramanian laboratories, Cambridge, United Kingdom

    • • - Led the bioinformatics team developing computational approaches to study epigenetic changes in DNA damage and understanding how they affect cancer biology in humans in collaboration with experimental chemists and biologists

        - Invented and patented a new method for mapping epigenetics modifications in DNA as well as developed experience in WGS, RNA-seq, ChIP-seq, CLIP-seq and chemical and antibody enrichment strategies, as well as BS-seq, shRNA and CRISPR genome-wide screens, and single-cell sequencing for target prioritisation.

        - Co-authored multiple publications in Nature journals (https://scholar.google.co.uk/citations?user=qRdu6_YAAAAJ) and a patent in new high-throughput sequencing methods

        - Presented results at international conferences in genomics and bioinformatics in the US, UK and Benelux.

        - Co-supervised PhD students and postdoctoral researchers.

        - Managed the computational and data management infrastructure of the research group in collaboration with IT: a computing cluster, two group servers and a data archive.

        - Created a framework to version control research code produced in the group using git and GitHub (https://github.com/sblab-bioinformatics)

        - Delivered multiple training courses in bioinformatics, genomics, programming, and data analysis and management- Led the bioinformatics team developing computational approaches to study epigenetic changes in DNA damage and understanding how they affect cancer biology in humans in collaboration with experimental chemists and biologists - Invented and patented a new method for mapping epigenetics modifications in DNA as well as developed experience in WGS, RNA-seq, ChIP-seq, CLIP-seq and chemical and antibody enrichment strategies, as well as BS-seq, shRNA and CRISPR genome-wide screens, and single-cell sequencing for target prioritisation. - Co-authored multiple publications in Nature journals (https://scholar.google.co.uk/citations?user=qRdu6_YAAAAJ) and a patent in new high-throughput sequencing methods - Presented results at international conferences in genomics and bioinformatics in the US, UK and Benelux. - Co-supervised PhD students and postdoctoral researchers. - Managed the computational and data management infrastructure of the research group in collaboration with IT: a computing cluster, two group servers and a data archive. - Created a framework to version control research code produced in the group using git and GitHub (https://github.com/sblab-bioinformatics) 

• Review Editor

  Frontiers Jul 2020 - Present · 

  • • - Frontiers in Bioinformatics https://www.frontiersin.org/journals/bioinformatics
      - Areas: Drug discovery and Bioinformatics- Frontiers in Bioinformatics https://www.frontiersin.org/journals/bioinformatics - Areas: Drug discovery and Bioinformatics

• Research Associate in Bioinformatics and Computational Biology

  Cancer Research UK Cambridge Institute 2015 - 2020 · Prof. Sir Shankar Balasubramanian laboratories, Cambridge Biomedical Campus

  • • - Led the bioinformatics team developing computational approaches to study epigenetic changes in DNA damage and understanding how they affect cancer biology in humans in collaboration with experimental chemists and biologists

      - Invented and patented a new method for mapping epigenetics modifications in DNA as well as developed experience in WGS, RNA-seq, ChIP-seq, CLIP-seq and chemical and antibody enrichment strategies, as well as BS-seq, shRNA and CRISPR genome-wide screens, and single-cell sequencing for target prioritisation.

      - Co-authored multiple publications in Nature journals (https://scholar.google.co.uk/citations?user=qRdu6_YAAAAJ) and a patent in new high-throughput sequencing methods

      - Presented results at international conferences in genomics and bioinformatics in the US, UK and Benelux.

      - Co-supervised PhD students and postdoctoral researchers.

      - Managed the computational and data management infrastructure of the research group in collaboration with IT: a computing cluster, two group servers and a data archive.

      - Created a framework to version control research code produced in the group using git and GitHub (https://github.com/sblab-bioinformatics)

      - Delivered multiple training courses in bioinformatics, genomics, programming, and data analysis and management- Led the bioinformatics team developing computational approaches to study epigenetic changes in DNA damage and understanding how they affect cancer biology in humans in collaboration with experimental chemists and biologists - Invented and patented a new method for mapping epigenetics modifications in DNA as well as developed experience in WGS, RNA-seq, ChIP-seq, CLIP-seq and chemical and antibody enrichment strategies, as well as BS-seq, shRNA and CRISPR genome-wide screens, and single-cell sequencing for target prioritisation. - Co-authored multiple publications in Nature journals (https://scholar.google.co.uk/citations?user=qRdu6_YAAAAJ) and a patent in new high-throughput sequencing methods - Presented results at international conferences in genomics and bioinformatics in the US, UK and Benelux. - Co-supervised PhD students and postdoctoral researchers. - Managed the computational and data management infrastructure of the research group in collaboration with IT: a computing cluster, two group servers and a data archive. - Created a framework to version control research code produced in the group using git and GitHub (https://github.com/sblab-bioinformatics) - Delivered multiple training courses in bioinformatics, genomics, programming, and data analysis and management

• European Bioinformatics Institute | EMBL-EBI

  Prof. Dame Janet Thornton group, Wellcome Trust Genome Campus

  • Postdoctoral Fellow

    2014 - 2015 

  • PhD Student

    2011 - 2014

Education

• University of Cambridge

  Doctor of Philosophy - PhD, Bioinformatics and Molecular Biology 2011 - 2014

  • Activities and societies: Gonville and Caius College

• Universidad de Granada

  Master of Science - MS, Chemistry 2005 - 2010

  • Activities and societies: International Relations with University of California

  • • - Gained broad knowledge in all areas of Chemistry (Organic, Inorganic, Analytical, Biological, Physical and Theoretical)
      - Final year research project: Computational approaches to model the dynamics of proteins (José Cristóbal Martínez Herrerías group)
      - Developed international experience during internships abroad
      - Award to best MSc Chemistry student 2005-2010

• University of Seoul

  Summer internship, Finance, International Relations and Korean language 2009 - 2009

• UC Santa Barbara

  Master of Science - MS, Chemistry 2008 - 2009

  • • - One-year exchange student
      - Research project: Exploring the stiffness of DNA nanotubes (Deborah K. Fygenson's laboratory)

• Loyola University Chicago

  Summer internship, Chemistry 2008 - 2008